Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Program in Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Nat Cell Biol. 2018 Mar;20(3):228-230. doi: 10.1038/s41556-018-0049-8.
Exosomes are heterogeneous, nanoscale vesicles that mediate cellular communication. A study now leverages a size separation strategy to identify sub-classes of nanoparticles. Besides revealing a subtype without an encapsulating membrane, biochemical analyses show variation in vesicle cargo, suggesting that size is not the only driver of heterogeneity.
外泌体是具有异质性的纳米级囊泡，可介导细胞间通讯。一项新研究利用尺寸分离策略来鉴定纳米颗粒的亚类。除了鉴定出一种没有包膜的亚型外，生化分析还显示囊泡货物存在差异，这表明尺寸并不是异质性的唯一驱动因素。
