Department of Physiological Chemistry, Faculty of Chemistry , University of Vienna , Althanstraße 14, UZA II , 1090 Vienna , Austria.
J Agric Food Chem. 2019 Feb 27;67(8):2113-2119. doi: 10.1021/acs.jafc.8b06369. Epub 2019 Feb 18.
The nutritional value of food can be improved by the addition of bioactive compounds. However, most of these favorable food additives demonstrate low bioavailability because of their limited stability, solubility, and structural transformations upon digestion and absorption. One strategy to combat these limitations is to integrate bioactives into nanoparticles, although the mostly used artificial materials may result in immune system activation and fast clearing times. Therefore, novel, more biocompatible delivery systems are required. Extracellular vesicles are communication tools designed by evolution to transfer information between cells, organs, and whole organisms. Hence, these vesicles offer enormous potential for targeted bioactive compound delivery.
食物的营养价值可以通过添加生物活性化合物来提高。然而，由于这些有利的食品添加剂在消化和吸收过程中的稳定性、溶解度和结构转化有限，大多数都表现出低生物利用度。克服这些限制的一种策略是将生物活性物质整合到纳米粒子中，尽管最常用的人工材料可能导致免疫系统激活和快速清除时间。因此，需要新型、更具生物相容性的输送系统。细胞外囊泡是进化设计的用于在细胞、器官和整个生物体之间传递信息的通讯工具。因此，这些囊泡为靶向生物活性化合物输送提供了巨大的潜力。
