Mita T, Hanada S, Nishino N, Kuno T, Nakai H, Yamadori T, Mizoi Y, Tanaka C
Biol Psychiatry. 1986 Dec;21(14):1407-14. doi: 10.1016/0006-3223(86)90332-x.
Serotonin S2 and dopamine D2 receptors in the prefrontal cortex and caudate nucleus of postmortem brains of chronic schizophrenics were studied using 3H-ketanserin and 3H-spiperone, respectively. In the prefrontal cortex of schizophrenics, we found a significant decrease in the maximum number of 3H-ketanserin binding sites (Bmax), with no change in the dissociation constant (Kd). Conversely, both Bmax and Kd of 3H-spiperone binding to the caudate nucleus were significantly increased in the schizophrenic patients. There were no differences in receptor indices between patients who were taking neuroleptics until their death and those who had taken none for 2 months or more prior to death. These findings suggest that alterations in S2 receptors in the prefrontal cortex may reflect the disease process, per se, and that the increase in the number of D2 receptors in the caudate nucleus of schizophrenics is not due solely to neuroleptic medication.
分别使用3H-酮色林和3H-螺哌隆对慢性精神分裂症患者死后大脑前额叶皮质和尾状核中的5-羟色胺S2和多巴胺D2受体进行了研究。在精神分裂症患者的前额叶皮质中，我们发现3H-酮色林结合位点的最大数量（Bmax）显著降低，而解离常数（Kd）没有变化。相反，精神分裂症患者中，3H-螺哌隆与尾状核结合的Bmax和Kd均显著增加。直至死亡一直在服用抗精神病药物的患者与在死亡前2个月或更长时间未服用任何药物的患者之间，受体指标没有差异。这些发现表明，前额叶皮质中S2受体的改变可能本身就反映了疾病过程，并且精神分裂症患者尾状核中D2受体数量的增加并非仅由抗精神病药物治疗所致。
