Teräväinen H, Hietanen M, Stoessl J, Calne D B
Can J Neurol Sci. 1986 Nov;13(4 Suppl):546-58. doi: 10.1017/s031716710003729x.
Of all the movement disorders, Huntington's disease has been most consistently associated with dementia, while it is only over the last decade that intellectual cognitive decline have been recognized as common features of Parkinson's disease. It is now known that the pathology in these two conditions reflects differential involvement of the striatum. The Huntington lesion is primarily in the caudate, while the Parkinson lesion preferentially affects the putamen. Both conditions have more diffuse pathology, and dementia may also occur in a wide range of other extrapyramidal diseases, such as progressive supranuclear palsy, the parkinsonism-dementia complex of Guam, and certain spinocerebellar degenerations. Clinicopathological correlations will be reviewed in these disorders of primarily subcortical pathology, and comparisons will be made with Alzheimer's disease, a disorder of predominantly cortical pathology.
在所有运动障碍中，亨廷顿病一直与痴呆症最为密切相关，而直到过去十年，智力认知衰退才被公认为帕金森病的常见特征。现在已知这两种病症的病理反映了纹状体的不同受累情况。亨廷顿病的病变主要在尾状核，而帕金森病的病变则优先影响壳核。这两种病症都有更广泛的病理变化，痴呆症也可能发生在一系列其他锥体外系疾病中，如进行性核上性麻痹、关岛的帕金森病痴呆综合征以及某些脊髓小脑变性。本文将对这些主要为皮质下病理的病症进行临床病理相关性综述，并与主要为皮质病理的阿尔茨海默病进行比较。
