University of Tasmania, Menzies Institute for Medical Research, Hobart, Australia.
University of Turku, Department of Medicine, Turku, Finland; Turku University Hospital, Division of Medicine, Turku, Finland.
J Pediatr (Rio J). 2019 Mar-Apr;95(2):247-254. doi: 10.1016/j.jped.2018.01.002. Epub 2018 Feb 21.
Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify potentially modifiable factors affecting tracking.
Prospective cohort of 1735 children (45% females) who had serum sPLA2 enzyme activity levels and other cardiovascular disease risk factors measured in 1980 that were followed-up in 2001.
sPLA2 activity tracked from childhood to adulthood for males (r=0.39) and females (r=0.45). Those who decreased body mass index relative to their peers were more likely to resolve elevated childhood sPLA2 levels than have persistent elevated sPLA2 levels in childhood and adulthood. Those who consumed less fruit, and gained more body mass index relative to their peers, began smoking or were a persistent smoker between childhood and adulthood were more likely to develop incident elevated sPLA2 levels than those with persistent not elevated sPLA2 levels.
Childhood sPLA2 enzyme activity levels associate with adult sPLA2 levels 21 years later. Healthful changes in modifiable risk factors that occur between childhood and adulthood might prevent children from developing elevated sPLA2 levels in adulthood.
分泌型磷脂酶 A2（sPLA2）酶活性是心血管疾病的潜在炎症生物标志物。我们研究了 sPLA2 酶活性水平从儿童期到成年期的跟踪或持续性，并确定了可能影响跟踪的可改变因素。
前瞻性队列研究了 1735 名儿童（45%为女性），他们在 1980 年测量了血清 sPLA2 酶活性水平和其他心血管疾病危险因素，并在 2001 年进行了随访。
男性（r=0.39）和女性（r=0.45）的 sPLA2 活性从儿童期到成年期都有跟踪。与同龄人相比，体重指数下降的人更有可能降低儿童时期升高的 sPLA2 水平，而不是在儿童和成年期持续升高 sPLA2 水平。与持续不升高 sPLA2 水平的人相比，那些在儿童和成年期之间水果摄入较少、体重指数增加更多、开始吸烟或持续吸烟的人更容易出现新出现的升高 sPLA2 水平。
儿童时期的 sPLA2 酶活性水平与 21 年后的成年 sPLA2 水平相关。儿童期和成年期之间发生的可改变风险因素的健康变化可能会防止儿童在成年期出现升高的 sPLA2 水平。
