College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai, China.
Front Immunol. 2022 Feb 10;13:826794. doi: 10.3389/fimmu.2022.826794. eCollection 2022.
is the major farmed shrimp species worldwide. White spot disease due to white spot syndrome virus (WSSV) is severely affecting shrimp worldwide, causing extensive economic losses in culture. This is the first study that applied combined transcriptomic and metabolomic analysis to study the effects on the hepatopancreas after WSSV challenge. Our transcriptomic data revealed differentially expressed genes (DEGs) associated with immunity, apoptosis, the cytoskeleton and the antioxidant system in the hepatopancreas of . Metabolomic results showed that WSSV disrupts metabolic processes including amino acid metabolism, lipid metabolism and nucleotide metabolism. After challenged by WSSV, immune-related DEGs and differential metabolites (DMs) were detected in the hepatopancreas of , indicating that WSSV may damage the immune system and cause metabolic disorder in the shrimp. In summary, these results provide new insights into the molecular mechanisms underlying 's response to WSSV.
是全球主要养殖虾类品种。由白斑综合征病毒（WSSV）引起的白斑病严重影响着全球虾类养殖业，造成了巨大的经济损失。本研究首次应用转录组学和代谢组学联合分析的方法来研究 WSSV 感染对虾肝胰腺的影响。我们的转录组数据揭示了与虾肝胰腺中免疫、凋亡、细胞骨架和抗氧化系统相关的差异表达基因（DEGs）。代谢组学结果表明，WSSV 破坏了包括氨基酸代谢、脂质代谢和核苷酸代谢在内的代谢过程。在受到 WSSV 感染后，我们在虾肝胰腺中检测到与免疫相关的 DEGs 和差异代谢物（DMs），这表明 WSSV 可能会损害虾的免疫系统并导致代谢紊乱。总之，这些结果为虾对 WSSV 反应的分子机制提供了新的见解。
