烟酰胺对N-甲基-N'-硝基-N-亚硝基胍诱导的杀伤和突变的影响。
The effect of nicotinamide on N-methyl-N'-nitro-N-nitrosoguanidine induced killing and mutation.
作者信息
Bhattacharyya N, Bhattacharjee S B
出版信息
Chem Biol Interact. 1986 Dec;60(3):287-95. doi: 10.1016/0009-2797(86)90059-1.
PMID:2947708
Abstract
Nicotinamide, an inhibitor of poly(ADP-ribose) synthesis has been found to increase the killing of Chinese hamster V-79 cells induced by N-methyl-N'-nitro-N-nitrosoguanidine in concentration dependent manner. Such treatment also decreased the induced mutation. The nature of the results obtained was similar to those obtained earlier with benzamide, another inhibitor.
摘要
烟酰胺，一种聚（ADP - 核糖）合成抑制剂，已被发现能以浓度依赖的方式增加N - 甲基 - N'- 硝基 - N - 亚硝基胍诱导的中国仓鼠V - 79细胞的杀伤作用。这种处理还降低了诱导突变。所获得结果的性质与早期使用另一种抑制剂苯甲酰胺所获得的结果相似。
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