揭示角质细胞中的黑洞。
Shining a Light on Black Holes in Keratinocytes.
机构信息
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
J Invest Dermatol. 2018 Mar;138(3):486-489. doi: 10.1016/j.jid.2017.11.002.
The mechanisms by which melanins are transferred from melanocytes and stored within keratinocytes to generate skin pigmentation are hotly debated. Correia et al. and Hurbain et al. provide evidence that melanin cores of melanosomes are secreted from melanocytes and taken up and stored within non-degradative membranous organelles in keratinocytes in the basal epidermis of human skin.
黑素体的黑素核心从黑素细胞分泌出来，并被基底表皮层的角质细胞内非降解性膜细胞器摄取和储存，从而产生皮肤色素沉着，这一机制一直存在争议。Correia 等人和 Hurbain 等人提供了证据，证明了这一点。
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