Neurological Clinic and Policlinic, Department of Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Institute for Neuropathology, University of Göttingen Medical Center, Robert-Koch-Str. 40, D-37099 Göttingen, Germany.
Neurosci Biobehav Rev. 2018 Jun;89:85-98. doi: 10.1016/j.neubiorev.2018.02.012. Epub 2018 Feb 23.
Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.
尽管小脑在多发性硬化症（MS）中具有重要的功能和显著的临床影响，但直到最近几年才受到广泛关注。现在已经确定，小脑不仅在各种感觉运动网络中发挥关键作用，而且在认知行为过程中也发挥关键作用，而认知行为过程是 MS 患者主要受影响的领域。关于 MS 中小脑受累的组织病理学和磁共振成像（MRI）研究证据越来越多，但是将这些病理发现与临床功能障碍联系起来仍然具有挑战性。技术上的一些有前途的进展可能会提高小脑内病理变化的检测能力，从而阐明病理与残疾的关系。
