Division of Cardiology, University of Colorado, Aurora, CO
Colorado Cardiovascular Outcomes Research, Aurora, CO.
J Am Heart Assoc. 2018 Feb 24;7(5):e008296. doi: 10.1161/JAHA.117.008296.
Lack of participation in cardiac rehabilitation (CR) and slow gait speed have both been associated with poor long-term outcomes in older adults after acute myocardial infarction (AMI). Whether the effect of CR participation on outcomes after AMI differs by gait speed is unknown.
We examined the association between gait speed and CR participation at 1 month after discharge after AMI, and death and disability at 1 year, in 329 patients aged ≥65 years enrolled in the TRIUMPH (Translational Research Investigating Underlying Disparities in Recovery From Acute Myocardial Infarction: Patients' Health Status) registry. Among these patients, 177 (53.7%) had slow gait speed (<0.8 m/s) and 109 (33.1%) participated in CR. Patients with slow gait speed were less likely to participate in CR compared with patients with normal gait speed (27.1% versus 40.1%; =0.012). In unadjusted analysis, CR participants with normal gait speed had the lowest rate of death or disability at 1 year (9.3%), compared with those with slow gait speed and no CR participation (43.2%). After adjustment for cardiovascular risk factors and cognitive impairment, both slow gait speed (odds ratio, 2.30; 95% confidence interval, 1.30-4.06) and non-CR participation (odds ratio, 2.34; 95 confidence interval, 1.22-4.48) were independently associated with death or disability at 1 year. The effect of CR on the primary outcome did not differ by gait speed (=0.70).
CR participation is associated with reduced risk for death or disability after AMI. The beneficial effect of CR participation does not differ by gait speed, suggesting that slow gait speed alone should not preclude referral to CR for older adults after AMI.
缺乏参与心脏康复(CR)和缓慢的步速都与老年人急性心肌梗死(AMI)后长期预后不良有关。CR 参与对 AMI 后结局的影响是否因步速而异尚不清楚。
我们研究了 329 名年龄≥65 岁的患者在 AMI 出院后 1 个月时的步速与 CR 参与情况,以及 1 年时的死亡和残疾情况,这些患者均来自 TRIUMPH(翻译研究调查急性心肌梗死恢复中潜在的差异:患者健康状况)登记处。在这些患者中,177 名(53.7%)有缓慢的步速(<0.8 m/s),109 名(33.1%)参与了 CR。与步速正常的患者相比,步速较慢的患者更不可能参与 CR(27.1%比 40.1%;=0.012)。在未调整分析中,步速正常且参与 CR 的患者 1 年时的死亡率或残疾率最低(9.3%),而步速较慢且未参与 CR 的患者死亡率或残疾率最高(43.2%)。在调整心血管危险因素和认知障碍后,缓慢的步速(比值比,2.30;95%置信区间,1.30-4.06)和不参与 CR(比值比,2.34;95%置信区间,1.22-4.48)均与 1 年时的死亡或残疾独立相关。CR 对主要结局的影响不因步速而异(=0.70)。
CR 参与与 AMI 后死亡或残疾风险降低相关。CR 参与的有益效果不因步速而异,这表明老年人 AMI 后,仅步速缓慢不应排除向 CR 转诊。