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2 型糖尿病患者中抑郁障碍的患病率及其相关因素:来自国际糖尿病和抑郁治疗与认知(INTERPRET-DD)研究的结果,该研究是在 14 个国家开展的合作研究。

Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET-DD) study, a collaborative study carried out in 14 countries.

机构信息

The Open University, School of Health, Wellbeing and Social Care, UK.

Department of Psychology, Middlesex University, UK.

出版信息

Diabet Med. 2018 Jun;35(6):760-769. doi: 10.1111/dme.13611. Epub 2018 Mar 30.

Abstract

AIMS

To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.

METHODS

People with diabetes aged 18-65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.

RESULTS

A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (P<0.0001), a lower level of education (P<0.05), doing less exercise (P<0.01), higher levels of diabetes distress (P<0.0001) and a previous diagnosis of major depressive disorder (P<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0-29.6%).

CONCLUSIONS

Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes.

摘要

目的

评估不同国家 2 型糖尿病患者中抑郁障碍的患病率和管理情况。

方法

在 14 个国家招募年龄在 18-65 岁、在门诊接受治疗的糖尿病患者,并进行精神病学访谈。参与者完成了患者健康问卷和糖尿病问题区域量表。收集人口统计学和医疗记录数据。

结果

共有 2783 名 2 型糖尿病患者(45.3%为男性,糖尿病病程平均为 8.8 年)参与了研究。总体而言,10.6%的患者被诊断为当前患有重度抑郁症,17.0%的患者报告有中度至重度抑郁症状(患者健康问卷得分>9)。多变量分析显示,在控制国家因素后,当前重度抑郁症与性别(女性)(P<0.0001)、教育程度较低(P<0.05)、运动较少(P<0.01)、糖尿病困扰程度较高(P<0.0001)和先前诊断为重度抑郁症(P<0.0001)显著相关。在记录于医疗记录中的有或没有当前重度抑郁症或中度至重度抑郁症状的患者中,接受过诊断或任何治疗的比例极低,在许多国家甚至不存在(0-29.6%)。

结论

我们的国际研究是此类研究中规模最大的一次,表明糖尿病患者经常患有抑郁障碍,也存在明显的抑郁症状。我们的研究结果表明,识别和适当治疗心理和精神问题并不是常规做法,这表明缺乏改善临床结果所需的全面糖尿病管理方法。

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