Kozlova S I, Dadali E L, Prytkov A N, Bol'shakova L P, Sibiriakova L G
Genetika. 1986 Oct;22(10):2534-9.
The data are presented on prevalence and clinical patterns of Huntington disease in Shamkhor region of Azerbaijan, where about 126.8 thousand inhabitants live. Population, demographic and genealogical data show that high prevalence of Huntington disease in that region is determined by the founder effects, reinforced later by extended reproduction of the population. Linkage analysis using the affected sib-pair method failed to reveal a linkage between Huntington's chorea locus and HLA, AB0, MN systems. Significant probability of linkage to Huntington's chorea locus was calculated for Gc marker.
本文展示了阿塞拜疆沙姆霍尔地区亨廷顿病的患病率及临床模式，该地区约有12.68万居民。人口、人口统计学和谱系数据表明，该地区亨廷顿病的高患病率是由奠基者效应决定的，随后因人口的持续繁衍而加剧。采用患病同胞对法进行连锁分析，未发现亨廷顿舞蹈病基因座与HLA、AB0、MN系统之间存在连锁关系。对于Gc标记物，计算出了与亨廷顿舞蹈病基因座连锁的显著概率。
