Govoni V, Pavoni M, Granieri E, Carreras M, Malagù S, Gandini E, Del Senno L
Istituto di Clinica Neurologica, Università di Ferrara.
Riv Neurol. 1988 Nov-Dec;58(6):235-40.
In the context of a multidisciplinary study program whose purpose is to investigate the genetic aspects of Huntington's Chorea (HC), the authors conducted an epidemiological descriptive research extended to the population residing in the province of Ferrara in a time period including the years from 1971 to 1987. On December 31st, 1987 we estimated a prevalence rate of 1.89 cases of HC per 100,000 inhabitants; in the years 1971-1987 the incidence rate was of 0.11 per 100,000/year and the mortality rate of 0.06 per 100,000/year. In the last years considered for the study, the incidence and the prevalence showed a relative increase indicating that HC still exists in the ferrarese population, despite a greater public awareness. With the aim to organize preventive actions and to reach the preclinical diagnosis of the disease we singled out 83 subjects at risk the study area.
在一个旨在研究亨廷顿舞蹈症（HC）遗传因素的多学科研究项目背景下，作者开展了一项流行病学描述性研究，研究对象为居住在费拉拉省的人群，研究时间段涵盖1971年至1987年。1987年12月31日，我们估计HC的患病率为每10万居民中有1.89例；在1971 - 1987年期间，发病率为每年每10万中有0.11例，死亡率为每年每10万中有0.06例。在研究的最后几年中，发病率和患病率呈现相对增长，这表明尽管公众意识有所提高，但HC在费拉拉人群中仍然存在。为了组织预防行动并实现该疾病的临床前诊断，我们在研究区域挑选出了83名有风险的受试者。
