Hutchings P R, Varey A M, Cooke A
Immunology. 1986 Nov;59(3):445-50.
SJL mice are shown to be defective in their ability to develop suppressor cells following stimulation with Con A, a polyclonal T-cell activator. They make a normal proliferative response to this mitogen. In addition to this suppressor T-cell defect, the SJL mouse (unlike most mouse strains) does not develop a spontaneous antibody response to bromelain-treated autologous red blood cells (BrMRBC) in vitro. Although the SJL makes a normal proliferative response to LPS, antibody-forming cells against bromelain-treated autologous red blood cells are not increased following LPS in vivo nor does it manifest an increased response to SRBC or TNP. This may signify the presence of a functional B-cell defect in these animals. DBA mice are also shown, in this report, to have small numbers of antibody-forming cells to bromelain-treated autologous red blood cells but to be capable of responding to LPS in vivo with an increase in SRBC and TNP antibody responses.
已证明，在用多克隆T细胞激活剂刀豆蛋白A刺激后，SJL小鼠产生抑制细胞的能力存在缺陷。它们对这种促细胞分裂剂有正常的增殖反应。除了这种抑制性T细胞缺陷外，SJL小鼠（与大多数小鼠品系不同）在体外不会对菠萝蛋白酶处理的自体红细胞（BrMRBC）产生自发抗体反应。尽管SJL对LPS有正常的增殖反应，但体内LPS处理后，针对菠萝蛋白酶处理的自体红细胞的抗体形成细胞并未增加，对SRBC或TNP的反应也未增强。这可能表明这些动物存在功能性B细胞缺陷。在本报告中还显示，DBA小鼠对菠萝蛋白酶处理的自体红细胞有少量抗体形成细胞，但能够在体内对LPS作出反应，SRBC和TNP抗体反应增加。
