Glassman M, Kaplan M, Spivak W
J Pediatr Gastroenterol Nutr. 1986 Nov-Dec;5(6):966-9. doi: 10.1097/00005176-198611000-00026.
A 13-year-old girl presented with a history of fever, arthritis, conjunctivitis, abdominal pain, and diarrhea. Colonoscopy and barium enema were consistent with Crohn's disease. A renal biopsy, performed because of persistent proteinuria and hematuria in the absence of obstruction to the urinary tract, revealed diffuse proliferative necrotizing glomerulonephritis: IgG, IgM, and C3 were deposited on the involved glomeruli. Circulating immune complexes were present in her serum. This immune-complex glomerulonephritis represents a previously unreported extraintestinal manifestation of inflammatory bowel disease.
一名13岁女孩有发热、关节炎、结膜炎、腹痛和腹泻病史。结肠镜检查和钡灌肠检查结果与克罗恩病相符。因存在持续性蛋白尿和血尿且尿路无梗阻而行肾活检，结果显示为弥漫性增殖性坏死性肾小球肾炎：免疫球蛋白G、免疫球蛋白M和补体C3沉积于受累肾小球。其血清中存在循环免疫复合物。这种免疫复合物性肾小球肾炎是炎症性肠病一种此前未报告的肠外表现。
