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人类肠道微生物群与健康和阿尔茨海默病。

Human Gut Microbiota in Health and Alzheimer's Disease.

机构信息

Medical University of Warsaw, Department of General Biology and Parasitology, Warsaw, Poland.

出版信息

J Alzheimers Dis. 2018;62(2):549-560. doi: 10.3233/JAD-170908.


DOI:10.3233/JAD-170908
PMID:29480188
Abstract

Gut microbiota plays a crucial role in human health and disease. The alterations in the composition of gut microbiota may cause the onset of certain human pathologies. One of these is Alzheimer's disease (AD). High-fat diets, administration of antibiotics, lack of probiotics and/or prebiotics in diet increase the risk of AD. On the other hand, modulation of the composition of gut microbiota may decrease the risk of AD and be able to slow down the progression of AD.

摘要

肠道微生物群在人类健康和疾病中起着至关重要的作用。肠道微生物群组成的改变可能导致某些人类疾病的发生。其中之一就是阿尔茨海默病(AD)。高脂肪饮食、抗生素的使用、饮食中缺乏益生菌和/或益生元会增加 AD 的发病风险。另一方面,调节肠道微生物群的组成可能会降低 AD 的风险,并能够减缓 AD 的进展。

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[1]
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Acta Pharmacol Sin. 2025-2-26

[2]
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J Prev Alzheimers Dis. 2025-4

[3]
The gut microbiota regulates diabetic retinopathy in adult rats.

Front Microbiol. 2025-1-29

[4]
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[5]
Exploring Causal Relationships Between Gut Microbiota and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.

J Alzheimers Dis Rep. 2024-7-5

[6]
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[7]
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[8]
The Role of Diet and Gut Microbiota in Alzheimer's Disease.

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[9]
Advances in the prevention and treatment of Alzheimer's disease based on oral bacteria.

Front Psychiatry. 2023-12-13

[10]
From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes.

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