Department of Geriatrics, Radboud University Medical Centre, Nijmegen, The Netherlands.
Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
J Alzheimers Dis. 2018;62(2):579-581. doi: 10.3233/JAD-171083.
Prevention trials in subjects with mild cognitive impairment (MCI), especially lifestyle interventions, can be difficult to carry out, particularly the recruitment and retention of subjects. We experienced these challenges in our multi-site one-year exercise trial in MCI, NeuroExercise. Trial recruitment rates differed significantly across sites; the non-medical sport university site, providing free access to a range of group exercise in a sports environment, proved far more successful than memory clinics linked to hospitals. This suggests that non-medical settings and a non-medical research community facilitating physical activities may be important factors in recruitment of subjects with MCI for large prevention trials.
在轻度认知障碍（MCI）患者中进行预防试验，特别是生活方式干预，可能具有挑战性，尤其是招募和保留受试者方面。我们在 MCI 的多中心为期一年的运动试验——NeuroExercise 中遇到了这些挑战。试验的招募率在不同地点有显著差异；提供在体育环境中参加一系列团体运动的免费机会的非医疗体育大学地点，比与医院相关联的记忆诊所成功得多。这表明，非医疗环境和促进体育活动的非医疗研究社区可能是招募 MCI 患者参加大型预防试验的重要因素。
