帕金森病患者视网膜结构的进行性变化。
Progressive Changes in the Retinal Structure of Patients with Parkinson's Disease.
机构信息
Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
出版信息
J Parkinsons Dis. 2018;8(1):85-92. doi: 10.3233/JPD-171184.
BACKGROUND
Many optical coherence tomography (OCT) studies have reported alterations in the retinal nerve fiber layer (RNFL) in Parkinson's disease (PD) and other neurodegenerative diseases. However, whether retinal alterations are a biomarker for PD is still controversial.
OBJECTIVE
To investigate potential correlations between PD and morphological changes in retina using OCT and to determine its usefulness as a biomarker of disease progression in PD.
METHODS
We performed a cross-sectional study on patients with PD (N = 37) and age-matched controls (N = 42), followed by a longitudinal study of the PD patients (N = 22) over approximately 2.5 years.
RESULTS
The average retinal nerve fiber layer (RNFL) thickness (p < 0.001), total macular thickness (p = 0.001), and macular volume (p = 0.001) were decreased in PD patients compared to controls and had further decreased at the follow-up visit (p < 0.05 for all). The average RNFL thickness and the total thickness of macular were negatively correlated with age in PD patients at baseline. Linear regression analysis revealed that age (p = 0.002, p = 0.003, respectively) and LEDD (p = 0.011, p = 0.013, respectively) were correlated to total thickness and volume of macular in 22 PD patients in the follow-up study. However, no correlation was found between RNFL and other parameters.
CONCLUSIONS
PD progression is associated with pronounced retinal structure changes, which can be quantified by OCT. Patterns of RNFL and macular damage detected by the noninvasive technology of OCT can be a useful biomarker for evaluating the progression of PD.
背景
许多光学相干断层扫描（OCT）研究报告称，帕金森病（PD）和其他神经退行性疾病患者的视网膜神经纤维层（RNFL）发生了改变。然而，视网膜改变是否是 PD 的生物标志物仍存在争议。
目的
使用 OCT 研究 PD 与视网膜形态变化之间的潜在相关性，并确定其作为 PD 疾病进展的生物标志物的有用性。
方法
我们对 37 例 PD 患者（N=37）和年龄匹配的对照组（N=42）进行了横断面研究，随后对大约 2.5 年的 22 例 PD 患者进行了纵向研究。
结果
与对照组相比，PD 患者的平均视网膜神经纤维层（RNFL）厚度（p<0.001）、总黄斑厚度（p=0.001）和黄斑体积（p=0.001）均降低，且在随访时进一步降低（p<0.05 均）。PD 患者在基线时，平均 RNFL 厚度和黄斑总厚度与年龄呈负相关。线性回归分析显示，年龄（p=0.002，p=0.003，分别）和 LEDD（p=0.011，p=0.013，分别）与 22 例 PD 患者在随访研究中的黄斑总厚度和体积相关。然而，RNFL 与其他参数之间没有相关性。
结论
PD 进展与明显的视网膜结构变化相关，这些变化可以通过 OCT 来量化。OCT 无创技术检测到的 RNFL 和黄斑损伤模式可作为评估 PD 进展的有用生物标志物。
Zotero 插件