Satue Maria, Rodrigo Maria J, Obis Javier, Vilades Elisa, Gracia Hector, Otin Sofia, Fuertes Maria I, Alarcia Raquel, Crespo Jose A, Polo Vicente, Larrosa Jose M, Pablo Luis E, Garcia-Martin Elena
Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain 3Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain.
Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1151-1157. doi: 10.1167/iovs.16-20460.
To quantify changes in visual function parameters and in the retinal nerve fiber layer and macular thickness over a 5-year period in patients with Parkinson's disease (PD).
Thirty patients with PD and 30 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity, contrast sensitivity vision, color vision, and retinal evaluation with spectral-domain optical coherence tomography (SD-OCT). All subjects were reevaluated after 5 years to quantify changes in visual function parameters, the retinal nerve fiber layer, and macular thickness. Association between progressive ophthalmologic changes and disease progression was analyzed.
Changes were detected in visual function parameters and retinal nerve fiber layer thickness in patients compared with controls. Greater changes were found during the follow-up in the PD group than healthy subjects in visual acuity, contrast sensitivity, Lanthony color test (P < 0.016), in superotemporal and temporal retinal nerve fiber layer sectors (P < 0.001), and in macular thickness (all sectors except inner superior and inner inferior sectors, P < 0.001). Progressive changes in the retinal nerve fiber layer were associated with disease progression (r = 0.389, P = 0.028).
Progressive visual dysfunction, macular thinning, and axonal loss can be detected in PD. Analysis of the macular thickness and the retinal nerve fiber layer by SD-OCT can be useful for evaluating Parkinson's disease progression.
量化帕金森病（PD）患者在5年期间视觉功能参数、视网膜神经纤维层和黄斑厚度的变化。
30例PD患者和30名健康受试者接受了全面的眼科评估，包括视力、对比敏感度视力、色觉评估，以及使用光谱域光学相干断层扫描（SD-OCT）进行视网膜评估。所有受试者在5年后重新评估，以量化视觉功能参数、视网膜神经纤维层和黄斑厚度的变化。分析眼科渐进性变化与疾病进展之间的关联。
与对照组相比，患者的视觉功能参数和视网膜神经纤维层厚度出现了变化。在随访期间，PD组在视力、对比敏感度、兰托尼色觉测试（P < 0.016）、颞上和颞侧视网膜神经纤维层区域（P < 0.001）以及黄斑厚度（除内上和内下区域外的所有区域，P < 0.001）方面的变化比健康受试者更大。视网膜神经纤维层的渐进性变化与疾病进展相关（r = 0.389，P = 0.028）。
在PD患者中可检测到渐进性视觉功能障碍、黄斑变薄和轴突丢失。通过SD-OCT分析黄斑厚度和视网膜神经纤维层有助于评估帕金森病的进展。
