ICARE Eye Hospital and Postgraduate Institute, Noida, Uttar Pradesh, India.
Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Indian J Ophthalmol. 2018 Mar;66(3):433-438. doi: 10.4103/ijo.IJO_845_17.
The purpose of the study was to describe macular changes in treatment-naïve eyes with Eales disease using spectral domain optical coherence tomography (SD-OCT).
A cross-sectional study was done on 79 eyes of 66 patients with Eales disease. Best-corrected visual acuity (BCVA), slit-lamp biomicroscopy (SLB), indirect ophthalmoscopy, fundus fluorescein angiography (FFA), and quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT were performed.
Forty-six (58.2%) eyes had macular involvement as assessed with SD-OCT, while in 33 (41.8%) eyes, macula was not affected. Macular edema was the most common feature when macula was affected followed by epiretinal membrane. Mean CMT was higher (315.3 ± 102.3 μm) in eyes with macular involvement than those without it (243.8 ± 19.3 μm). Eyes with active vasculitis involving larger vessels and neovascularization had greater chance of macular involvement. SLB and FFA alone missed 28.3% and 50% eyes with macular abnormalities on SD-OCT, respectively.
While the clinical description of Eales disease points mainly to a peripheral location, macular involvement can be commonly picked up when SD-OCT is used. Macular involvement when present is associated with a poorer BCVA.
本研究旨在通过频域光相干断层扫描（SD-OCT）描述未经治疗的 Eales 病患者的黄斑变化。
对 66 例 Eales 病患者的 79 只眼进行了横断面研究。对所有患者均进行最佳矫正视力（BCVA）、裂隙灯生物显微镜（SLB）、间接检眼镜、眼底荧光血管造影（FFA）检查，并进行定量（黄斑中心厚度 [CMT]）和定性分析。
46 只（58.2%）眼的黄斑受 SD-OCT 评估影响，而 33 只（41.8%）眼的黄斑不受影响。黄斑水肿是最常见的特征，其次是视网膜内膜。黄斑受累眼的平均 CMT 高于黄斑未受累眼（315.3±102.3μm 比 243.8±19.3μm）。累及较大血管和新生血管的活动性血管炎的眼，更有可能发生黄斑受累。SLB 和 FFA 分别单独漏诊了 28.3%和 50%的黄斑异常眼。
尽管 Eales 病的临床描述主要指向周边位置，但当使用 SD-OCT 时，黄斑受累通常可以被发现。黄斑受累与较差的 BCVA 相关。
