University of Colorado Denver, Anschutz Medical Campus, School of Medicine, Department of Immunology and Microbiology, Denver, CO, USA.
Department of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Nat Rev Immunol. 2018 Feb 26;18(3):1. doi: 10.1038/nri.2018.13.
Memory-phenotype CD8 T cells exist in substantial numbers within hosts that have not been exposed to either foreign antigen or overt lymphopenia. These antigen-inexperienced memory-phenotype T cells can be divided into two major subsets: ‘innate memory’ T cells and ‘virtual memory’ T cells. Although these two subsets are nearly indistinguishable by surface markers alone, notable developmental and functional differences exist between the two subsets, which suggests that they represent distinct populations. In this Opinion article, we review the available literature on each subset, highlighting the key differences between these populations. Furthermore, we suggest a unifying model for the categorization of antigen-inexperienced memory-phenotype CD8 T cells.
在未接触过外来抗原或明显淋巴细胞减少的宿主中，存在大量具有记忆表型的 CD8 T 细胞。这些无抗原经验的记忆表型 T 细胞可分为两个主要亚群：“先天记忆”T 细胞和“虚拟记忆”T 细胞。尽管仅通过表面标志物，这两个亚群几乎无法区分，但这两个亚群之间存在明显的发育和功能差异，这表明它们代表不同的群体。在这篇观点文章中，我们回顾了关于每个亚群的现有文献，强调了这些群体之间的关键差异。此外，我们提出了一个统一的模型，用于对无抗原经验的记忆表型 CD8 T 细胞进行分类。
