通过醇介导的 Minisci 型自由基共轭加成实现色酮的位点特异性羟烷基化。
Site-specific hydroxyalkylation of chromones via alcohol mediated Minisci-type radical conjugate addition.
机构信息
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China.
出版信息
Org Biomol Chem. 2018 Mar 14;16(11):1823-1827. doi: 10.1039/c8ob00392k.
A metal-free site-specific C2-hydroxyalkylation of chromones through the Minisci-type reaction using simple alcohols was developed. This transformation proceeds via radical sp C-H activation and subsequent conjugate addition, generating a series of C2-hydroxyalkylated chromanones in moderate to good yields. Besides, ethers were also compatible in this Minisci reaction, leading to corresponding C2 ether-substituted chromanones.
开发了一种通过 Minisci 型反应，无需金属催化剂，利用简单醇实现色酮的位点特异性 C2-羟烷基化反应。该转化通过自由基 spC-H 活化和随后的共轭加成进行，以中等至良好的收率生成一系列 C2-羟烷基化的色满酮。此外，醚也适用于这种 Minisci 反应，得到相应的 C2 醚取代的色满酮。
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