Department of Microbiology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Emil‑Ramann‑Str. 4, 85354, Freising, Germany.
Biosciences Center, National Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, CO, 80401, USA.
World J Microbiol Biotechnol. 2018 Feb 26;34(3):42. doi: 10.1007/s11274-018-2424-9.
An increasing number of researchers working in biology, biochemistry, biotechnology, bioengineering, bioinformatics and other related fields of science are using biological molecules. As the scientific background of the members of different scientific communities is more diverse than ever before, the number of scientists not familiar with the rules for non-ambiguous designation of genetic elements is increasing. However, with biological molecules gaining importance through biotechnology, their functional and unambiguous designation is vital. Unfortunately, naming genes and proteins is not an easy task. In addition, the traditional concepts of bioinformatics are challenged with the appearance of proteins comprising different modules with a respective function in each module. This article highlights basic rules and novel solutions in designation recently used within the community of bacterial geneticists, and we discuss the present-day handling of gene and protein designations. As an example we will utilize a recent mischaracterization of gene nomenclature. We make suggestions for better handling of names in future literature as well as in databases and annotation projects. Our methodology emphasizes the hydrolytic function of multi-modular genes and extracellular proteins from bacteria.
越来越多从事生物学、生物化学、生物技术、生物工程、生物信息学和其他相关科学领域的研究人员正在使用生物分子。由于不同科学领域成员的科学背景比以往任何时候都更加多样化，越来越多不熟悉遗传元素明确指定规则的科学家出现了。然而，随着生物技术使生物分子变得越来越重要，对其进行功能明确的指定是至关重要的。不幸的是，给基因和蛋白质命名并不是一件容易的事。此外，随着具有不同功能模块的蛋白质的出现，传统的生物信息学概念受到了挑战，每个模块都有相应的功能。本文重点介绍了细菌遗传学家社区最近使用的指定规则和新的解决方案，并讨论了目前基因和蛋白质指定的处理方式。作为一个例子，我们将利用最近对基因命名法的错误描述。我们为在未来的文献以及数据库和注释项目中更好地处理名称提出了建议。我们的方法强调了细菌中多模块基因和细胞外蛋白的水解功能。
