Centre National de la Recherche Scientifique, CNRS UMR 7257, 13288 Marseille, France and Aix-Marseille Université, AFMB, 163 Avenue de Luminy, 13288 Marseille, France.
Nucleic Acids Res. 2014 Jan;42(Database issue):D490-5. doi: 10.1093/nar/gkt1178. Epub 2013 Nov 21.
The Carbohydrate-Active Enzymes database (CAZy; http://www.cazy.org) provides online and continuously updated access to a sequence-based family classification linking the sequence to the specificity and 3D structure of the enzymes that assemble, modify and breakdown oligo- and polysaccharides. Functional and 3D structural information is added and curated on a regular basis based on the available literature. In addition to the use of the database by enzymologists seeking curated information on CAZymes, the dissemination of a stable nomenclature for these enzymes is probably a major contribution of CAZy. The past few years have seen the expansion of the CAZy classification scheme to new families, the development of subfamilies in several families and the power of CAZy for the analysis of genomes and metagenomes. This article outlines the changes that have occurred in CAZy during the past 5 years and presents our novel effort to display the resolution and the carbohydrate ligands in crystallographic complexes of CAZymes.
碳水化合物活性酶数据库（CAZy；http://www.cazy.org）提供了在线和持续更新的基于序列的家族分类访问，将序列与组装、修饰和分解寡糖和多糖的酶的特异性和 3D 结构联系起来。根据现有文献，定期添加和维护功能和 3D 结构信息。除了酶学家在寻求 CAZymes 的经过审核的信息时使用该数据库之外，为这些酶分配稳定的命名法可能是 CAZy 的主要贡献之一。在过去的几年中，CAZy 的分类方案已经扩展到了新的家族，几个家族中的亚家族也得到了发展，CAZy 还具有分析基因组和宏基因组的功能。本文概述了过去 5 年中 CAZy 发生的变化，并介绍了我们在显示 CAZymes 晶体复合物分辨率和碳水化合物配体方面的新努力。
