通过烯醛和β-硅基烯酮获得对映体富集的有机硅烷：卡宾有机催化。
Access to Enantioenriched Organosilanes from Enals and β-Silyl Enones: Carbene Organocatalysis.
作者信息
Zhang Yuxia, Huang Jie, Guo Yingying, Li Lin, Fu Zhenqian, Huang Wei
机构信息
Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816, China.
Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), Xi'an, 710072, China.
出版信息
Angew Chem Int Ed Engl. 2018 Apr 16;57(17):4594-4598. doi: 10.1002/anie.201800483. Epub 2018 Mar 15.
Herein, an efficient route to enantioenriched organosilanes, containing two consecutive stereogenic centers, from enals and β-silyl enones under carbene organocatalysis is described. Under mild reaction conditions, this transition-metal-free strategy exhibits a broad substrate scope, and excellent diastereo- and enantioselectivity.
本文描述了一种在卡宾有机催化作用下，从烯醛和β-硅基烯酮出发，高效合成含有两个连续手性中心的对映体富集有机硅烷的方法。在温和的反应条件下，这种无过渡金属策略具有广泛的底物范围，以及出色的非对映和对映选择性。
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