Yang Wei, Zhang Tao, Li Zhou, Ren Xinling, Huang Bo, Zhu Guijin, Jin Lei
Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, JieFang Avenue, Wuhan, People's Republic of China.
Medicine (Baltimore). 2018 Jan;97(2):e9577. doi: 10.1097/MD.0000000000009577.
To evaluate the combined effect of endometrial thickness and pattern on clinical outcomes in females following in vitro fertilization/intracytoplasmic sperm injection and frozen-thawed embryo transfer (IVF/ICSI-FET).FET cycles using at least 1 morphological good-quality blastocyst conducted between 2012 and 2013 at a university-based reproductive center were reviewed retrospectively. Endometrial ultrasonographic characteristics were recorded on the day of progesterone supplementation in FET cycles. In the combined analysis, endometrial thickness groups (group 1: equal or < 8 mm; group 2: >8 mm) were subdivided into 2 endometrial patterns (pattern A: triple-line; pattern B: no-triple line). Clinical pregnancy rate, spontaneous abortion rate, and live birth rate in different groups were analyzed.A total of 1512 cycles were reviewed. The results showed that significant differences in endometrial thickness and pattern were observed between the pregnant group (n = 1009) and no pregnant group (n = 503) (P < .05), while no significant differences were found between the live birth group (n = 844) and no live birth group (n = 668). Combined analysis revealed those with endometrial thickness > 8 mm and triple-line endometrial pattern had significant higher clinical pregnancy rates, while spontaneous abortion rates and live birth rates showed no significant differences among these subgroups.This study suggested neither individual nor combined analysis of endometrial thickness and pattern had predicting effects on live birth following IVF treatments, and embryo quality might be the one that really has effects.
评估体外受精/卵胞浆内单精子注射及冻融胚胎移植（IVF/ICSI-FET）后女性子宫内膜厚度和形态对临床结局的联合影响。回顾性分析2012年至2013年在某大学附属生殖中心进行的至少移植1枚形态良好的囊胚的FET周期。记录FET周期中补充孕酮当天的子宫内膜超声特征。在联合分析中，将子宫内膜厚度组（第1组：等于或<8 mm；第2组：>8 mm）再细分为2种子宫内膜形态（形态A：三线型；形态B：非三线型）。分析不同组的临床妊娠率、自然流产率和活产率。共回顾了1512个周期。结果显示，妊娠组（n = 1009）和未妊娠组（n = 503）之间的子宫内膜厚度和形态存在显著差异（P <.05），而活产组（n = 844）和未活产组（n = 668）之间未发现显著差异。联合分析显示，子宫内膜厚度>8 mm且呈三线型子宫内膜形态者临床妊娠率显著更高，而这些亚组之间的自然流产率和活产率无显著差异。本研究表明，无论是单独分析还是联合分析子宫内膜厚度和形态，对IVF治疗后的活产均无预测作用，胚胎质量可能才是真正起作用的因素。
