Wu Yu, Gao Xiaohong, Lu Xiang, Xi Ji, Jiang Shan, Sun Yin, Xi Xiaowei
Reproductive Medicine, Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated First People's Hospital, No, 650, New Songjiang Road, Shanghai 201620, China.
Reprod Biol Endocrinol. 2014 Oct 9;12:96. doi: 10.1186/1477-7827-12-96.
The goal of this study was to assess the association between endometrial thickness on the chorionic gonadotropin (hCG) day and in vitro fertilization and embryo transfer (IVF-ET) outcome in normal responders after GnRH antagonist administration.
A retrospective cohort study was performed in normal responders with GnRH antagonist administration from January 2011-December 2013. Patients were divided into four groups according to endometrial thickness, as follows: <7 mm (group 1), > = 7- < 8 mm (group 2), > = 8- < 14 mm (group 3), and > =14 mm (group 4).
A total of 2106 embryo transfer cycles were analyzed. The pregnancy rate (PR) was 44.87%.The clinical pregnancy rate, ongoing pregnancy rate and the implantation rate (17.28%, 13.79%, 10.17%, respectively) were significantly lower in group 1 compared to the other three groups (p < 0.05). The miscarriage rate was higher in patients with endometrial thickness less than 7 mm. The clinical pregnancy rate, ongoing pregnancy rate and implantation rate were highest in patients with endometrial thickness higher than 14 mm, but showed no difference in patients with those of endometrial thickness between 8-14 mm.
There is a correlation between endometrial thickness measured on hCG day and clinical outcome in normal responders with GnRH antagonist administration. The pregnancy rate was lower in patients with endometrial thickness less than 7 mm compared with patients with endometrial thickness more than 7 mm.
本研究的目的是评估在使用促性腺激素释放激素（GnRH）拮抗剂的正常反应者中，绒毛膜促性腺激素（hCG）日的子宫内膜厚度与体外受精-胚胎移植（IVF-ET）结局之间的关联。
对2011年1月至2013年12月使用GnRH拮抗剂的正常反应者进行了一项回顾性队列研究。根据子宫内膜厚度将患者分为四组，如下：<7mm（第1组），≥7-<8mm（第2组），≥8-<14mm（第3组），以及≥14mm（第4组）。
共分析了2106个胚胎移植周期。妊娠率（PR）为44.87%。与其他三组相比，第1组的临床妊娠率、持续妊娠率和着床率（分别为17.28%、13.79%、10.17%）显著较低（p<0.05）。子宫内膜厚度小于7mm的患者流产率较高。子宫内膜厚度高于14mm的患者临床妊娠率、持续妊娠率和着床率最高，但子宫内膜厚度在8-14mm之间的患者之间无差异。
在使用GnRH拮抗剂的正常反应者中，hCG日测量的子宫内膜厚度与临床结局之间存在相关性。与子宫内膜厚度大于7mm的患者相比，子宫内膜厚度小于7mm的患者妊娠率较低。
