Deckert Amy L, Gheihman Galina, Nissim Rinat, Chung Cynthia, Schimmer Aaron D, Zimmermann Camilla, Rodin Gary
Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 2M9, Canada; Global Institute of Psychosocial, Palliative and End-of-Life Care (GIPPEC), University of Toronto and University Health Network, Toronto, Ontario, M5G 1Z6, Canada.
Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, United States.
Leuk Res. 2018 Apr;67:86-91. doi: 10.1016/j.leukres.2018.02.009. Epub 2018 Feb 15.
The symptom burden of acute myeloid leukemia (AML) and its treatment can accelerate physical deconditioning and impair mobility and quality of life. In the present study, we explore the subjective experience of functional capacity in people living with AML.
A secondary qualitative analysis was performed on a subset of interviews (n = 21) obtained from an observational cohort study of people with acute leukemia. Conventional content analysis was employed to identify key themes and concepts.
Participants valued their physical function to the extent that it was required to pursue personally meaningful activities and interests. We identified Meaningful Activity as an overarching goal of participants. Three interrelated themes captured the obstacles participants reported facing when attempting to realize this goal: Compromised Body, Threatened Identity, and Shrinking World. Adaptation was common across themes, representing the strategies employed to overcome such challenges. Themes were consistent across participants, despite the variability in disease states at the time of the interview.
Dynamic interactions between physical, psychological, and environmental factors affect the pursuit and achievement of meaningful activity among people living with AML. It may be important to consider personal incentives when designing interventions for physical rehabilitation in this patient population.
急性髓系白血病（AML）及其治疗带来的症状负担会加速身体机能衰退，损害活动能力和生活质量。在本研究中，我们探讨了AML患者对功能能力的主观体验。
对从一项急性白血病患者观察性队列研究中获取的部分访谈（n = 21）进行二次定性分析。采用常规内容分析法确定关键主题和概念。
参与者重视自身的身体功能，因为这是追求个人有意义的活动和兴趣所必需的。我们将“有意义的活动”确定为参与者的首要目标。三个相互关联的主题体现了参与者在试图实现这一目标时所面临的障碍：身体受损、身份受威胁和世界缩小。适应在各个主题中都很常见，代表了克服此类挑战所采用的策略。尽管访谈时疾病状态存在差异，但各主题在参与者中是一致的。
身体、心理和环境因素之间的动态相互作用影响着AML患者对有意义活动的追求和实现。在为该患者群体设计身体康复干预措施时，考虑个人动机可能很重要。
