Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Cancer Biomark. 2019;25(3):259-273. doi: 10.3233/CBM-192437.
The expression of neuropilin-1 (NRP-1) in Epstein-Barr virus (EBV)-associated lymphomas and its relationships with clinicopathological parameters was investigated.
The researchers compared 111 cases of patients with lymphoma to 20 cases of reactive lymphoid hyperplasia. In situ hybridization was applied to observe the expression of EBV-encoded RNA (EBER) in lymphomas, and immunohistochemistry was used to detect the NRP-1 expression in lymphoma tissues and lymph node tissues with reactive hyperplasia.
In these 111 cases, the EBER of 62 cases (55.9%) appeared positive. NRP-1 was relatively highly expressed in lymphomas (P= 0.019). Further, NRP-1 showed higher expression in lymphomas with positive EBER than in negative ones. A comprehensive analysis revealed that NRP-1 was differently expressed in NK/T-cell lymphoma, Hodgkin's lymphoma, diffuse large B-cell lymphoma, and anaplastic large cell lymphoma (P= 0.027). Moreover, highly expressed NRP-1 was found to be a useful independent prognostic factor in assessing overall survival and progression-free survival rates in cases of non-Hodgkin's lymphoma (NHL).
NRP-1 exhibited higher expression in lymphomas, and it was positively expressed in EBV-positive lymphomas. Moreover, highly expressed NRP-1 can be used as an undesirable independent prognostic factor in NHL.
研究了神经纤毛蛋白-1（NRP-1）在 EBV 相关淋巴瘤中的表达及其与临床病理参数的关系。
研究人员将 111 例淋巴瘤患者与 20 例反应性淋巴组织增生患者进行比较。应用原位杂交观察淋巴瘤中 EBV 编码 RNA（EBER）的表达，应用免疫组化检测反应性增生淋巴结组织和淋巴瘤组织中 NRP-1 的表达。
在这 111 例患者中，62 例（55.9%）的 EBER 呈阳性。NRP-1 在淋巴瘤中表达较高（P=0.019）。进一步研究发现，EBER 阳性的淋巴瘤中 NRP-1 的表达高于 EBER 阴性的淋巴瘤。综合分析显示，NRP-1 在 NK/T 细胞淋巴瘤、霍奇金淋巴瘤、弥漫性大 B 细胞淋巴瘤和间变性大细胞淋巴瘤中的表达存在差异（P=0.027）。此外，高表达的 NRP-1 被发现是评估非霍奇金淋巴瘤（NHL）患者总生存率和无进展生存率的有用独立预后因素。
NRP-1 在淋巴瘤中表达较高，在 EBV 阳性淋巴瘤中呈阳性表达。此外，高表达的 NRP-1 可作为 NHL 不良的独立预后因素。
