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妇科肿瘤学中的新兴分子成像技术

Emerging Molecular Imaging Techniques in Gynecologic Oncology.

作者信息

Lin Gigin, Lai Chyong-Huey, Yen Tzu-Chen

机构信息

Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fu-Shin Street, Kueishan, Taoyuan 333, Taiwan.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fu-Shin Street, Kueishan, Taoyuan 333, Taiwan.

出版信息

PET Clin. 2018 Apr;13(2):289-299. doi: 10.1016/j.cpet.2017.11.011. Epub 2018 Jan 10.

Abstract

Molecular imaging (mainly PET and MR imaging) has played important roles in gynecologic oncology. Emerging MR-based technologies, including DWI, CEST, DCE-MR imaging, MRS, and DNP, as well as FDG-PET and many novel PET radiotracers, will continuously improve practices. In combination with radiomics analysis, a new era of decision making in personalized medicine and precisely guided radiation treatment planning or real-time surgical interventions is being entered into, which will directly impact on patient survival. Prospective trials with well-defined endpoints are encouraged to evaluate the multiple facets of these emerging imaging tools in the management of gynecologic malignancies.

摘要

分子成像(主要是正电子发射断层扫描和磁共振成像)在妇科肿瘤学中发挥了重要作用。新兴的基于磁共振成像的技术,包括扩散加权成像(DWI)、化学交换饱和转移成像(CEST)、动态对比增强磁共振成像(DCE-MR成像)、磁共振波谱分析(MRS)和动态核极化(DNP),以及氟代脱氧葡萄糖正电子发射断层扫描(FDG-PET)和许多新型PET放射性示踪剂,将不断改善临床实践。结合放射组学分析,正在进入个性化医疗决策以及精确引导放射治疗计划或实时手术干预的新时代,这将直接影响患者的生存率。鼓励开展具有明确终点的前瞻性试验,以评估这些新兴成像工具在妇科恶性肿瘤管理中的多个方面。

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