Department of Pharmaceutics and Pharmaceutical Technology, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Addiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Int J Mol Sci. 2021 Feb 5;22(4):1631. doi: 10.3390/ijms22041631.
Angiogenesis is one of the hallmarks of cancer. Several studies have shown that vascular endothelium growth factor (VEGF) plays a leading role in angiogenesis progression. Antiangiogenic medication has gained substantial recognition and is commonly administered in many forms of human cancer, leading to a rising interest in cancer therapy. However, this treatment method can lead to a deteriorating outcome of resistance, invasion, distant metastasis, and overall survival relative to its cytotoxicity. Furthermore, there are significant obstacles in tracking the efficacy of antiangiogenic treatments by incorporating positive biomarkers into clinical settings. These shortcomings underline the essential need to identify additional angiogenic inhibitors that target numerous angiogenic factors or to develop a new method for drug delivery of current inhibitors. The great benefits of nanoparticles are their potential, based on their specific properties, to be effective mechanisms that concentrate on the biological system and control various important functions. Among various therapeutic approaches, nanotechnology has emerged as a new strategy for treating different cancer types. This article attempts to demonstrate the huge potential for targeted nanoparticles and their molecular imaging applications. Notably, several nanoparticles have been developed and engineered to demonstrate antiangiogenic features. This nanomedicine could effectively treat a number of cancers using antiangiogenic therapies as an alternative approach. We also discuss the latest antiangiogenic and nanotherapeutic strategies and highlight tumor vessels and their microenvironments.
血管生成是癌症的特征之一。有几项研究表明，血管内皮生长因子（VEGF）在血管生成进展中起主导作用。抗血管生成药物已得到广泛认可，并广泛应用于多种人类癌症，这使得人们对癌症治疗产生了浓厚的兴趣。然而，与细胞毒性相比，这种治疗方法可能导致耐药性、侵袭、远处转移和总体生存率的恶化。此外，将阳性生物标志物纳入临床环境以跟踪抗血管生成治疗的效果存在重大障碍。这些缺点强调了识别针对多种血管生成因子的额外血管生成抑制剂或开发当前抑制剂的药物输送新方法的必要性。纳米粒子的巨大优势在于，基于其特定的性质，它们具有成为集中于生物系统并控制各种重要功能的有效机制的潜力。在各种治疗方法中，纳米技术已成为治疗不同癌症类型的新策略。本文试图展示靶向纳米粒子及其分子成像应用的巨大潜力。值得注意的是，已经开发和设计了几种纳米粒子来展示抗血管生成特性。这种纳米医学可以有效地使用抗血管生成疗法作为替代方法来治疗多种癌症。我们还讨论了最新的抗血管生成和纳米治疗策略，并强调了肿瘤血管及其微环境。
