Thomsen P, Bjursten L M, Ericson L E
Scand J Plast Reconstr Surg. 1986;20(2):173-82. doi: 10.3109/02844318609006316.
An experimental model is presented that allows qualitative as well as quantitative studies of the soft tissue response to implant materials used in reconstructive surgery. Plugs of non-alloyed titanium and polymers (Teflon, Delrin) were inserted into the abdominal wall of rats, with a portion of the plug penetrating through the peritoneum into the abdominal cavity. The tissue reaction was evaluated by means of light and electron microscopy for up to 9 weeks after insertion. Titanium implants were in direct contact with the connective tissue without intervening inflammatory cells. The defect in the peritoneum was sealed by a close apposition of the mesothelial membrane to the titanium surface and no connective tissue surrounded the intra-peritoneal portion of the plug. In contrast, a fibrous capsule surrounded the intra-peritoneal portion of Teflon and Delrin implants. A reactive zone consisting of active macrophages and giant cells was present at the surface of these implants separating the implant from the surrounding fibrous capsule. This study shows that the tissue response at the interface to foreign materials can be studied using light and electron microscopic techniques and that profound differences in tissue response exist between different materials.
本文提出了一种实验模型，该模型可对重建手术中使用的植入材料的软组织反应进行定性和定量研究。将非合金钛栓和聚合物（聚四氟乙烯、聚甲醛）植入大鼠腹壁，栓的一部分穿透腹膜进入腹腔。在植入后长达9周的时间内，通过光学显微镜和电子显微镜对组织反应进行评估。钛植入物与结缔组织直接接触，其间无炎症细胞。腹膜缺损通过间皮膜紧密贴附于钛表面而封闭，栓的腹腔内部分周围无结缔组织。相比之下，聚四氟乙烯和聚甲醛植入物的腹腔内部分被纤维囊包围。在这些植入物表面存在一个由活跃巨噬细胞和巨细胞组成的反应区，将植入物与周围纤维囊分隔开。这项研究表明，可使用光学显微镜和电子显微镜技术研究异物界面处的组织反应，并且不同材料之间的组织反应存在显著差异。
