Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China; Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
Sleep Med. 2018 Mar;43:40-46. doi: 10.1016/j.sleep.2017.11.1146. Epub 2018 Jan 31.
Restless legs syndrome (RLS) and Parkinson's disease (PD) are common neurological disorders that respond to dopaminergic therapy. RLS prevalence among people with PD varies widely (0-38%) in the literature, complicating efforts to understand whether the two diseases might be associated.
The databases Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were searched for observational and case-control studies of RLS prevalence in PD. Eligible studies were meta-analyzed using Stata 12.0.
Pooled RLS prevalence in PD among various patient populations was 14%, and prevalence in Asia (12%) was slightly lower than outside Asia (16%). Prevalence was higher among patients who had previously received PD treatment (15%) than among drug-naïve patients (11%). Prevalence of RLS was higher in female PD patients (13%) than in male patients (11%). RLS prevalence was much higher among PD patients than among healthy controls (OR 2.86, 95% CI 2.10-3.90; p < 0.001).
This meta-analysis may provide the first reliable pooled estimate of RLS prevalence in PD, and strong evidence that RLS risk is higher among PD patients than among healthy individuals.
不宁腿综合征（RLS）和帕金森病（PD）是常见的神经疾病，对多巴胺能治疗有反应。RLS 在 PD 患者中的患病率在文献中差异很大（0-38%），这使得理解这两种疾病是否可能相关变得复杂。
在 Web of Science、PubMed、Embase、中国国家知识基础设施、万方和 SinoMed 数据库中搜索 RLS 在 PD 中的患病率的观察性和病例对照研究。使用 Stata 12.0 对合格研究进行荟萃分析。
在各种患者人群中，PD 中 RLS 的总患病率为 14%，亚洲（12%）的患病率略低于亚洲以外地区（16%）。在先前接受过 PD 治疗的患者（15%）中，患病率高于未接受药物治疗的患者（11%）。PD 女性患者（13%）的 RLS 患病率高于男性患者（11%）。PD 患者的 RLS 患病率明显高于健康对照组（OR 2.86，95%CI 2.10-3.90；p<0.001）。
这项荟萃分析可能提供了 PD 中 RLS 患病率的第一个可靠的汇总估计，并且有强有力的证据表明 RLS 风险在 PD 患者中高于健康人群。
