Poroshina Iu A, Luss L V, Gervazieva V G
Ter Arkh. 1986;58(10):76-8.
The authors describe the results of clinical, allergological and immunological examination of 35 patients with urticaria caused by pyrazolone derivatives. Clinically, the patients with pyrazolone-induced urticaria were marked by chronic diseases requiring the prolonged and frequent intake of the analgesics, pyrazolone derivatives. The allergological examination of the 35 patients with pyrazolone-induced urticaria showed that only one of the patients had pollenosis, 6 patients had IgG-mediated reactions to egg protein and one patient to penicillin. For specific diagnosis of drug allergy use was made of the natural leukocyte migration test in vivo according to A. D. Ado. The test appeared positive with analgin in all the 35 patients suffering from pyrazolone-induced urticaria. It represents a simple and accessible method for specific diagnosis of drug allergy both in inpatients and in those visiting allergological rooms at the polyclinics. The immunological examination made with the aid of the histograms demonstrated an appreciable reduction in the content of D-phagocytosing neutrophils. The latter fact might explain the presence of multiple chronic foci of infection in patients with pyrazolone-induced urticaria. Such patients manifested a decrease in C3 that might be related to immediate activation of the alternative pathway of complement by pyrazolone derivatives.
作者描述了对35例由吡唑酮衍生物引起的荨麻疹患者进行临床、变态反应学和免疫学检查的结果。临床上，吡唑酮诱发的荨麻疹患者的特点是患有需要长期频繁服用镇痛药（吡唑酮衍生物）的慢性病。对35例吡唑酮诱发的荨麻疹患者进行的变态反应学检查显示，只有1例患者患有花粉症，6例患者对卵蛋白有IgG介导的反应，1例患者对青霉素有反应。为了进行药物过敏的特异性诊断，采用了根据A.D.阿多的体内自然白细胞迁移试验。在所有35例患有吡唑酮诱发的荨麻疹的患者中，安乃近试验均呈阳性。它是一种简单且可及的方法，可用于住院患者以及在综合门诊的变态反应科就诊患者的药物过敏特异性诊断。借助直方图进行的免疫学检查显示，吞噬D的中性粒细胞含量明显减少。后一事实可能解释了吡唑酮诱发的荨麻疹患者存在多个慢性感染灶的原因。这类患者表现出C3降低，这可能与吡唑酮衍生物立即激活补体替代途径有关。
