Kjeldsen S E, Lande K, Gjesdal K, Westheim A, Foss O P, Leren P, Eide I K
Am Heart J. 1987 Jan;113(1):151-5. doi: 10.1016/0002-8703(87)90023-8.
Beta-thromboglobulin (BTG) is a platelet-specific release product. Plasma BTG was significantly increased (p less than 0.01) in 50-year-old, untreated essential hypertensive men (1.22 +/- 0.13 nmol/L, n = 39, mean +/- SE) compared to 50-year-old, healthy normotensive control men (0.82 +/- 0.07 nmol/L, n = 31). Plasma BTG in the hypertensive group correlated significantly with the total serum cholesterol concentration (r = 0.47, p less than 0.01) and with the atherogenic cholesterol fractions low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol (r = 0.50, p less than 0.01). In the normotensive group, no significant correlation was observed between plasma BTG and total serum cholesterol (r = 0.14) or between plasma BTG and LDL + VLDL cholesterol (r = 0.08). Neither was any significant correlation found between plasma BTG and serum high-density lipoprotein (HDL) cholesterol or total triglycerides in either group. Thus, middle-aged men with untreated essential hypertension have an increased blood platelet release reaction related to their concentrations of atherogenic blood lipids. This relationship may be of pathogenetic importance for atherogenesis in hypertension.
β-血小板球蛋白（BTG）是一种血小板特异性释放产物。与50岁健康血压正常的男性对照组（0.82±0.07 nmol/L，n = 31）相比，50岁未经治疗的原发性高血压男性患者血浆BTG显著升高（p＜0.01）（1.22±0.13 nmol/L，n = 39，均值±标准误）。高血压组血浆BTG与血清总胆固醇浓度显著相关（r = 0.47，p＜0.01），与致动脉粥样硬化胆固醇组分低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）胆固醇也显著相关（r = 0.50，p＜0.01）。在血压正常组，未观察到血浆BTG与血清总胆固醇之间存在显著相关性（r = 0.14），也未观察到血浆BTG与LDL + VLDL胆固醇之间存在显著相关性（r = 0.08）。两组中血浆BTG与血清高密度脂蛋白（HDL）胆固醇或总甘油三酯之间均未发现显著相关性。因此，未经治疗的中年原发性高血压男性患者的血小板释放反应增强，这与其致动脉粥样硬化血脂浓度有关。这种关系可能对高血压患者动脉粥样硬化的发病机制具有重要意义。
