Gjesdal K, Kjeldsen S E, Lande K, Westheim A, Aakesson I, Foss O P, Leren P, Eide I K
Acta Med Scand Suppl. 1986;714:125-8. doi: 10.1111/j.0954-6820.1986.tb08980.x.
50 year old men with moderate, essential hypertension (n = 39) were compared to normotensive males of similar age (n = 31). The hypertensive men were heavier (10 kg in average, p less than 0.01), and had a higher pulse rate (5 beats per minute (p less than 0.05). Plasma beta-thromboglobulin, a marker of platelet release reaction, was 49% higher in the hypertensive group (p less than 0.01). Total cholesterol, LDL + VLDL cholesterol and serum triglycerides were not significantly different between the groups. In the hypertensive group, plasma beta-thromboglobulin concentration correlated significantly with total cholesterol (r = 0.47, p less than 0.01) as well as with LDL + VLDL cholesterol (r = 0.50, p less than 0.01). In the normotensive group no such correlation was found. The results suggest activation of platelets in hypertension, and suggest that in hypertension, even a normal cholesterol concentration may influence platelet function.
将39名50岁患有中度原发性高血压的男性与31名年龄相仿的血压正常男性进行比较。高血压男性体重更重（平均重10千克，p<0.01），脉搏率更高（每分钟高5次，p<0.05）。作为血小板释放反应标志物的血浆β-血小板球蛋白在高血压组中高出49%（p<0.01）。两组之间总胆固醇、低密度脂蛋白+极低密度脂蛋白胆固醇和血清甘油三酯无显著差异。在高血压组中，血浆β-血小板球蛋白浓度与总胆固醇显著相关（r = 0.47，p<0.01），也与低密度脂蛋白+极低密度脂蛋白胆固醇显著相关（r = 0.50，p<0.01）。在血压正常组中未发现此类相关性。结果表明高血压患者血小板被激活，且表明在高血压中，即使胆固醇浓度正常也可能影响血小板功能。
