Lande K, Os I, Kjeldsen S E, Westheim A, Aakesson I, Hjermann I, Eide I, Gjesdal K
Acta Med Scand Suppl. 1986;714:129-32. doi: 10.1111/j.0954-6820.1986.tb08981.x.
Hypertensive men aged 42 (n = 35) were compared to normotensive men of similar age (n = 44). Platelet numbers were similar in the two groups, but hypertensive men had larger venous platelets than the normotensive (7.46 versus 7.12 femtoliter, p = 0.01). Plasma concentration of beta-thromboglobulin (BTG), a marker of platelet release reaction, was increased in arterial blood in hypertension (40 versus 21 micrograms/l, p = 0.02). The normotensive subjects had markedly higher BTG concentration in venous compared to arterial blood (p less than 0.01), but this arterio-venous difference was not present in the hypertensive group. Twelve normotensive subjects received infused saline, which did not induce changes in platelet variables. Adrenaline was infused to 13 hypertensive and 12 normotensive subjects, with dose gradually increasing to 0.04 microgram/kg/min. Platelet count increased in both groups, but significantly more in the hypertensive group. Platelet volume and BTG both increased markedly in the hypertensive group, but not in the normotensive men. Thus, young men with hypertension have increased platelet activity and increased sensitivity to exogenous adrenaline.
将42岁的高血压男性（n = 35）与年龄相仿的血压正常男性（n = 44）进行比较。两组的血小板数量相似，但高血压男性的静脉血小板比血压正常者更大（7.46对7.12飞升，p = 0.01）。β-血小板球蛋白（BTG）是血小板释放反应的标志物，其血浆浓度在高血压患者的动脉血中升高（40对21微克/升，p = 0.02）。与动脉血相比，血压正常受试者静脉血中的BTG浓度明显更高（p < 0.01），但高血压组不存在这种动静脉差异。12名血压正常受试者输注生理盐水，未引起血小板变量变化。对13名高血压受试者和12名血压正常受试者输注肾上腺素，剂量逐渐增加至0.04微克/千克/分钟。两组的血小板计数均增加，但高血压组增加得更显著。高血压组的血小板体积和BTG均明显增加，而血压正常男性则无此变化。因此，年轻高血压男性的血小板活性增加，对外源性肾上腺素的敏感性增加。
