Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Department of Clinical Cannabinoid Research, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Am J Clin Dermatol. 2024 Nov;25(6):951-966. doi: 10.1007/s40257-024-00891-y. Epub 2024 Oct 5.
Cannabidiol (CBD) is a non-psychotropic cannabinoid with multiple pharmacological properties. Cannabidiol has attracted growing attention in the cosmetic industry, with an increasing number of CBD-containing skincare products on the market in recent years. The aim of this review is to evaluate the current evidence on the use of CBD for cosmetic purposes. Following an overview of CBD and the endocannabinoid system in the skin, we summarize pre-clinical and clinical studies that address the potential of CBD in cosmetic dermatology. Available in vitro and in vivo evidence suggests that CBD has anti-oxidant, anti-inflammatory, moisturizing, anti-acne, wound-healing, and anti-aging properties. However, only a few clinical studies have been conducted on the use of CBD in the skin. In addition, there is a critical need to develop an efficient drug-delivery system for topical/transdermal application of CBD. Further research, including clinical and pharmacokinetic studies, are needed to fully evaluate the role of CBD in cosmetic dermatology.
大麻二酚（CBD）是一种具有多种药理学特性的非精神活性大麻素。近年来，含有 CBD 的护肤品在市场上越来越多，这引起了化妆品行业的极大关注。本综述旨在评估 CBD 用于美容目的的现有证据。在概述 CBD 和皮肤中的内源性大麻素系统后，我们总结了探讨 CBD 在美容皮肤科中应用潜力的临床前和临床研究。现有的体外和体内证据表明，CBD 具有抗氧化、抗炎、保湿、抗痤疮、伤口愈合和抗衰老特性。然而，仅有少数临床研究探讨了 CBD 在皮肤中的应用。此外，还需要开发一种有效的药物输送系统，以实现 CBD 的局部/经皮应用。需要进一步的研究，包括临床和药代动力学研究，以充分评估 CBD 在美容皮肤科中的作用。
