Niemann Catherin
Center for Molecular Medicine Cologne (CMMC); University of Cologne; Institute of Pathology; Cologne, Germany.
Dermatoendocrinol. 2009 Mar;1(2):64-7. doi: 10.4161/derm.1.2.8486.
The sebaceous gland is renewed throughout adult life and homeostasis of this particular organ is controlled by a precise interplay of hormones, cytokines, signalling molecules and mediators of the lipid metabolism. Although the true function of sebaceous glands has yet to be fully determined, recent evidence demonstrates that normal homeostasis of the sebaceous gland and functional lipid metabolism of sebocytes is crucial for maintenance of the skin barrier. In addition, analysis of mutant mouse models revealed a close interdependency of the sebaceous gland with hair follicles because abnormal morphogenesis of sebaceous glands often results in degeneration of hair follicle structures. Anomalous regulation of sebaceous glands is involved in the pathogenesis of acne, one of the most prevalent human diseases, or could lead to formation of sebaceous hyperplasia and tumours. This review highlights some of the recent findings on the importance of signalling pathways controlling morphogenesis and differentiation of the sebaceous gland in vivo.
皮脂腺在成年期会持续更新，该特定器官的稳态由激素、细胞因子、信号分子和脂质代谢介质之间精确的相互作用所控制。尽管皮脂腺的真正功能尚未完全确定，但最近的证据表明，皮脂腺的正常稳态和皮脂细胞的功能性脂质代谢对于维持皮肤屏障至关重要。此外，对突变小鼠模型的分析揭示了皮脂腺与毛囊之间存在密切的相互依赖性，因为皮脂腺的异常形态发生通常会导致毛囊结构退化。皮脂腺的异常调节参与了痤疮（人类最常见的疾病之一）的发病机制，或可能导致皮脂腺增生和肿瘤的形成。本综述重点介绍了一些关于体内控制皮脂腺形态发生和分化的信号通路重要性的最新研究发现。
