a Division of Childhood Gastroenterology and Cystic Fibrosis, Department of Human Pathology in Adulthood and Childhood "G. Barresi" , University of Messina , Italy.
b Division of Neurogastroenterology and Motility, Department of Gastroenterology , Great Ormond Street Hospital and UCL , London , UK.
Curr Med Res Opin. 2018 Oct;34(10):1785-1791. doi: 10.1080/03007995.2018.1445983. Epub 2018 Mar 23.
This narrative review provides an update on cyclic vomiting syndrome pathogenesis, diagnosis and management, based upon studies published after the 2008 North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) official recommendations. The review began with a comprehensive PubMed/Medline search for "cyclic vomiting syndrome", "periodic syndromes" and "pediatrics" from 2000 up to October 2017. Additional papers were identified by reviewing the re-ference lists of retrieved publications. Cyclic vomiting syndrome is a severe, debilitating disorder of the brain-gut axis with unclear pathogenesis, that significantly affects long-term quality of life of affected children and their families. The 2008 NASPGHAN recommendations defined the major clinical, diagnostic and therapeutic peculiarities. Over the last 10 years, advancements in pathogenesis and diagnostic criteria have been made, and new prophylactic and therapeutic strategies have been proposed. These aspects are discussed in this manuscript. For the pediatrician, the major aim is to have early clinical suspicion to avoid diagnostic delay and to start adequate, phase-related, symptom-tailored management.
这篇叙述性综述基于 2008 年北美儿科学会胃肠病学、肝病学和营养学会（NASPGHAN）发布的官方建议后发表的研究，更新了周期性呕吐综合征的发病机制、诊断和治疗。综述首先在 PubMed/Medline 上以“周期性呕吐综合征”、“周期性综合征”和“儿科”为关键词，对 2000 年至 2017 年 10 月的文献进行了全面检索。通过检索检索到的文献的参考文献列表，确定了其他文献。周期性呕吐综合征是一种严重的、使人虚弱的脑-肠轴疾病，其发病机制尚不清楚，严重影响受影响儿童及其家庭的长期生活质量。2008 年 NASPGHAN 的建议定义了主要的临床、诊断和治疗特点。在过去的 10 年中，在发病机制和诊断标准方面取得了进展，并提出了新的预防和治疗策略。本文讨论了这些方面。对于儿科医生来说，主要目标是早期临床怀疑，以避免诊断延误，并开始进行适当的、与阶段相关的、针对症状的管理。
