从滇西乌头中分离得到两种具有抗炎活性的新型双 C-二萜生物碱。
Two new bis-C-diterpenoid alkaloids with anti-inflammation activity from Aconitum bulleyanum.
作者信息
Duan Xiao-Yan, Zhao Da-Ke, Shen Yong
机构信息
a College of Agriculture and Biotechnology , Yunnan Agricultural University , Kunming 650201 , China.
b School of Agriculture , Yunnan University , Kunming 650091 , China.
出版信息
J Asian Nat Prod Res. 2019 Apr;21(4):323-330. doi: 10.1080/10286020.2018.1439024. Epub 2018 Feb 27.
Two new bis-C-diterpenoid alkaloids, bulleyanines A and B (1 and 2), were isolated from Aconitum bulleyanum. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D and 2D NMR. Biological activity tests indicated that compound 1 exhibited significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages with the inhibition rate of 74.60% (40 μmol/L), while positive control dexamethasone gave 78.70% inhibition at 100 μg/ml.
从滇西乌头中分离得到两个新的双 - C - 二萜生物碱，即滇西乌头碱A和B（1和2）。通过包括紫外光谱（UV）、红外光谱（IR）、质谱（MS）、一维和二维核磁共振（1D和2D NMR）在内的综合光谱分析确定了它们的结构。生物活性测试表明，化合物1对脂多糖（LPS）激活的RAW264.7巨噬细胞中一氧化氮（NO）的产生具有显著抑制活性，抑制率为74.60%（40 μmol/L），而阳性对照地塞米松在100 μg/ml时的抑制率为78.70%。
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