Dennison Sarah R, Harris Frederick, Mura Manuela, Phoenix David A
School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom.
School of Forensic and Investigative Science, University of Central Lancashire Preston PR1 2HE, United Kingdom.
Curr Protein Pept Sci. 2018;19(8):823-838. doi: 10.2174/1389203719666180226155035.
Anionic antimicrobial peptides (AAMPs) with net charges ranging from -1 to -8 have been identified in frogs, toads, newts and salamanders across Africa, South America and China. Most of these peptides show antibacterial activity and a number of them are multifunctional, variously showing antifungal activity, anticancer action, neuropeptide function and the ability to potentiate conventional antibiotics. Antimicrobial mechanisms proposed for these AAMPs, include toroidal pore formation and the Shai-Huang-Matsazuki model of membrane interaction along with pH dependent amyloidogenesis and membranolysis via tilted peptide formation. The potential for therapeutic and biotechnical application of these AAMPs has been demonstrated, including the development of amyloid-based nanomaterials and antiviral agents. It is concluded that amphibian AAMPs represent an untapped potential source of biologically active agents and merit far greater research interest.
在非洲、南美洲和中国的青蛙、蟾蜍、蝾螈和火蜥蜴中，已鉴定出净电荷为 -1 至 -8 的阴离子抗菌肽（AAMP）。这些肽大多具有抗菌活性，其中一些具有多种功能，包括抗真菌活性、抗癌作用、神经肽功能以及增强传统抗生素的能力。针对这些 AAMP 提出的抗菌机制包括环形孔形成、膜相互作用的 Shai-Huang-Matsazuki 模型，以及 pH 依赖性淀粉样蛋白生成和通过倾斜肽形成的膜溶解。这些 AAMP 在治疗和生物技术应用方面的潜力已得到证明，包括基于淀粉样蛋白的纳米材料和抗病毒剂的开发。得出的结论是，两栖动物 AAMP 代表了一种尚未开发的生物活性剂潜在来源，值得进行更多的研究。
