Department of Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.
Immunology. 2018 Jul;154(3):354-362. doi: 10.1111/imm.12917. Epub 2018 Mar 30.
Due to imbalances between vascularity and cellular growth patterns, the tumour microenvironment harbours multiple metabolic stressors including hypoxia and acidosis, which have significant influences on remodelling both tumour and peritumoral tissues. These stressors are also immunosuppressive and can contribute to escape from immune surveillance. Understanding these effects and characterizing the pathways involved can identify new targets for therapy and may redefine our understanding of traditional anti-tumour therapies. In this review, the effects of hypoxia and acidosis on tumour immunity will be summarized, and how modulating these parameters and their sequelae can be a useful tool for future therapeutic interventions is discussed.
由于血管生成和细胞生长模式之间的失衡，肿瘤微环境中存在多种代谢应激因素，包括缺氧和酸中毒，这些因素对肿瘤和肿瘤周围组织的重塑有重大影响。这些应激因素还具有免疫抑制作用，可导致免疫逃避。了解这些影响并描述相关途径可以确定新的治疗靶点，并可能重新定义我们对传统抗肿瘤治疗的理解。在这篇综述中，将总结缺氧和酸中毒对肿瘤免疫的影响，并讨论调节这些参数及其后果如何成为未来治疗干预的有用工具。
