Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China; The Second People's Hospital of Gansu Province, Lanzhou, Gansu 730000, China.
Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China; Department of Oncology, The 181st Hospital of PLA, Guilin, Guangxi 541002, China.
J Immunol Res. 2016;2016:8605134. doi: 10.1155/2016/8605134. Epub 2016 Jun 20.
T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.
T 细胞在抗肿瘤免疫中发挥着重要作用，其表面的 T 细胞免疫球蛋白结构域和黏蛋白结构域蛋白-1（TIM-1）作为共刺激分子，对 T 细胞具有很强的调节作用。TIM-1 可调节和增强肿瘤相关的 1 型免疫反应。因此，TIM-1 共刺激途径可能是未来肿瘤免疫治疗的一个有前途的治疗靶点。本文综述了 TIM-1 的免疫调节和抗肿瘤作用。
