Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Biofactors. 2018 May;44(3):207-218. doi: 10.1002/biof.1419. Epub 2018 Feb 27.
Oxygen is a fundamental element for the life of a large number of living organisms allowing an efficient energetic utilization of substrates. Organisms relying on oxygen evolved complex structures for oxygen delivery and biochemical machineries dealing with its safe utilization and the ability to overcome the potentially harmful consequences of changes in oxygen availability. On fact, cells composing complex Eukaryotic organisms are set to live within an optimum narrow range of oxygen, quite specific for each cell type. Minute modifications of oxygen availability, either positive or negative, induce the expression of specific genes, the major actors of this responses being the transcription factors HIF and Nrf2 that control the attempt to cope with low oxygen (hypoxia) or to either high oxygen or to an oxygen "overflow," respectively. This review describes the interaction between these two transcription factors and their interaction with the transcription factor NF-κB acting as a pivotal determinant of final cell response. © 2018 BioFactors, 44(3):207-218, 2018.
氧气是大量生物生存的基本要素，它可以使基质得到有效的能量利用。依赖氧气的生物进化出了复杂的氧气输送结构和处理氧气安全利用的生化机制，以及克服氧气供应变化带来的潜在有害后果的能力。事实上，组成复杂真核生物的细胞被设定在一个非常特定于每种细胞类型的氧气最佳狭窄范围内生存。氧气供应的微小变化，无论是正的还是负的，都会诱导特定基因的表达，这两个转录因子 HIF 和 Nrf2 是这些反应的主要参与者，它们分别控制着对低氧（缺氧）或高氧或氧气“溢出”的应对尝试。这篇综述描述了这两个转录因子之间的相互作用，以及它们与转录因子 NF-κB 的相互作用，后者作为最终细胞反应的关键决定因素。©2018 BioFactors, 44(3):207-218, 2018.
