Kosyreva A M, Dzhalilova D Sh, Miroshnichenko E A, Makarova O V
Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):261-266. doi: 10.1007/s10517-025-06318-w. Epub 2025 Jan 6.
It was previously found that the severity of LPS-induced systemic inflammatory response (SIRS) in rats is determined by resistance to hypoxia and the level of Hif1a expression. Individual differences in the level of Hif1a and NFkb expression in the liver were studied in relation to the severity of inflammatory and immune reactions in LPS-induced SIRS in rats without previous placement in a ventilated decompression chamber. During the early periods after SIRS modeling, rats with high expression of the Hif1a and NFkb genes associated with increased expression of pro- and anti-inflammatory cytokines are identified. These animals have a high blood level of corticosterone, low number of neutrophils in the interalveolar septa, and a predominance of T cells over B cells in the peripheral blood. The obtained data can be used to develop new approaches to the individual prediction of the severity of sepsis and SIRS in intensive care units, which will increase the effectiveness of therapy and reduce mortality rate.
先前发现，大鼠中脂多糖诱导的全身炎症反应（SIRS）的严重程度由对缺氧的抵抗力和Hif1a表达水平决定。在未预先置于通风减压舱的大鼠中，研究了肝脏中Hif1a和NFkb表达水平的个体差异与脂多糖诱导的SIRS中炎症和免疫反应严重程度的关系。在SIRS建模后的早期，鉴定出Hif1a和NFkb基因高表达且与促炎和抗炎细胞因子表达增加相关的大鼠。这些动物血液中皮质酮水平高，肺泡间隔中嗜中性粒细胞数量少，外周血中T细胞多于B细胞。所获得的数据可用于开发在重症监护病房中对脓毒症和SIRS严重程度进行个体预测的新方法，这将提高治疗效果并降低死亡率。
