Lemcke Sanne, Parner Erik T, Bjerrum Merete, Thomsen Per H, Lauritsen Marlene B
Aarhus University Hospital, Aarhus, Denmark.
University of Aarhus, Aarhus, Denmark.
Infant Ment Health J. 2018 Mar;39(2):170-182. doi: 10.1002/imhj.21701. Epub 2018 Feb 27.
Studies have shown that children later diagnosed with autism spectrum disorders (ASD) in their first years of life might show symptoms in main developmental areas and that these signs might be sensed by the parents. The present study investigated in a large birth cohort if children later diagnosed with ASD had deviations at 6 and 18 months in areas such as the ability to self-regulate emotions, feeding, and sleeping. The study was based on prospective information collected from 76,322 mothers who participated in the Danish National Birth Cohort. When the children reached an average age of 11 years, 973 children with ASD and a control group of 300 children with intellectual disability (IDnoASD) were identified via Danish health registries. Associations were found between short periods of breast-feeding and the children later diagnosed with ASD and IDnoASD as well as associations at 18 months to deviations in regulation of emotions and activity. The similarities in these associations emphasize how difficult it is to distinguish between diagnoses early in life.
研究表明,日后在一岁内被诊断为自闭症谱系障碍(ASD)的儿童,在主要发育领域可能会出现症状,且这些迹象可能会被父母察觉。本研究在一个大型出生队列中调查了日后被诊断为ASD的儿童在6个月和18个月时,在自我情绪调节、进食和睡眠等方面是否存在偏差。该研究基于从76322名参与丹麦国家出生队列的母亲那里收集的前瞻性信息。当这些儿童平均年龄达到11岁时,通过丹麦健康登记系统确定了973名患有ASD的儿童和一个由300名智力残疾儿童组成的对照组(非ASD智力残疾组)。研究发现,母乳喂养时间短与日后被诊断为ASD和非ASD智力残疾组的儿童之间存在关联,以及在18个月时与情绪和活动调节偏差之间存在关联。这些关联中的相似之处凸显了在生命早期区分诊断是多么困难。