Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Av. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, CEP 312270-901, Brazil.
NIHR Applied Research Collaborative, Greater Manchester (NIHR ARC GM), Faculty of Biology, Medicine and Health, Division of Nursing, Midwifery and Social Work, Jean McFarlane Building, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
BMC Oral Health. 2022 Aug 10;22(1):341. doi: 10.1186/s12903-022-02366-0.
To estimate the prevalence of malocclusion in individuals with autism spectrum disorders (ASD) and to assess the relationship between ASD and malocclusion.
We searched electronic databases including PubMed, Scopus, Web of Science, Cochrane, Embase, SciELO LILACS, Proquest, OpenGrey and Google Scholar. There were no language or publication dates restrictions. Two researchers independently performed selection, data extraction and quality assessment. Quality assessment and risk of bias were evaluated through the Newcastle-Ottawa scale and ROBINS-E tool. Meta-analyses using random effect models were used to estimate pooled measures of prevalence of malocclusion characteristics in individuals with ASD and pooled odds ratio (OR) on the relationship between ASD and malocclusion characteristics. Subgroup meta-analyses were conducted according to children and adolescents, history of orthodontic treatment, and occurrence of other syndromes and medical conditions.
Searching identified 5549 papers with 238 were selected for full assessment. Eighteen cross-sectional studies were included according to inclusion criteria. Of them, eleven studies were considered of moderate quality. A judgement of critical risk of bias occurred for thirteen studies. The most prevalent malocclusion characteristics in individuals with ASD were crowding (33%; 95% CI 22 to 44%) and increased maxillary overjet (39%; 95% CI 23 to 54%). Individuals with ASD had higher odds of Angle's Class II (OR 1.92; 95% CI 1.36 to 2.72), Angle's Class III (OR 2.33; 95% CI 1.29 to 4.23), open bite (OR 1.96; 95% CI 1.21 to 3.16), and increased maxillary overjet (OR 1.53; 95% CI 1.06 to 2.21) than individuals without ASD.
Angle's Class II, Angle's Class III, anterior open bite and increased maxillary overjet were more prevalent in individuals with ASD than those without ASD. Further high-quality studies are needed.
评估自闭症谱系障碍（ASD）个体的错颌畸形患病率，并评估 ASD 与错颌畸形之间的关系。
我们检索了包括 PubMed、Scopus、Web of Science、Cochrane、Embase、SciELO LILACS、Proquest、OpenGrey 和 Google Scholar 在内的电子数据库。无语言或出版日期限制。两位研究人员独立进行了选择、数据提取和质量评估。通过 Newcastle-Ottawa 量表和 ROBINS-E 工具评估质量评估和偏倚风险。使用随机效应模型进行荟萃分析，以估计 ASD 个体错颌畸形特征的患病率汇总测量值，以及 ASD 与错颌畸形特征之间的汇总比值比（OR）。根据儿童和青少年、正畸治疗史以及其他综合征和医疗状况进行亚组荟萃分析。
搜索共确定了 5549 篇论文，其中 238 篇被选为全文评估。根据纳入标准，有 18 项横断面研究被纳入。其中，11 项研究被认为质量中等。13 项研究存在关键偏倚风险判断。在 ASD 个体中最常见的错颌畸形特征是拥挤（33%；95%CI 22%至 44%）和上颌前突增加（39%；95%CI 23%至 54%）。与无 ASD 的个体相比，ASD 个体发生 Angle 类 II（OR 1.92；95%CI 1.36 至 2.72）、Angle 类 III（OR 2.33；95%CI 1.29 至 4.23）、前牙开颌（OR 1.96；95%CI 1.21 至 3.16）和上颌前突增加（OR 1.53；95%CI 1.06 至 2.21）的可能性更高。
与无 ASD 的个体相比，Angle 类 II、Angle 类 III、前牙开颌和上颌前突增加在 ASD 个体中更为常见。需要进一步进行高质量的研究。
