Punatar Ruchi, Angkustsiri Kathleen, Kair Laura R, Tancredi Daniel J, Harvey Danielle J, Schmidt Rebecca J
Division of Developmental Behavioral Pediatrics, Department of Pediatrics, University of California Davis, Sacramento, CA, USA.
UC Davis MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Sacramento, CA, USA.
Child Psychiatry Hum Dev. 2024 Apr 24. doi: 10.1007/s10578-024-01700-7.
This study aimed to compare the breastfeeding (BF) duration of the younger siblings of children with ASD in an enriched-likelihood cohort for autism spectrum disorder (ASD), and to determine whether longer BF duration was associated with differences in neurodevelopmental outcomes in this cohort. Information on BF practices was collected via surveys in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) study. Developmental evaluations, including the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, were conducted by expert clinicians. Participants' neurodevelopmental outcome was classified by an algorithm into three groups: typical development, ASD, and non-typical development. The median duration of BF was 10.70 months (interquartile range of 12.07 months). There were no significant differences in the distribution of duration of BF among the three neurodevelopmental outcome categories. Children in this enriched-likelihood cohort who were breastfed for > 12 months had significantly higher scores on cognitive testing compared to those who were breastfed for 0-3 months. There was no significant difference in ASD symptomatology or ASD risk based on BF duration.
本研究旨在比较自闭症谱系障碍（ASD）高风险队列中患有ASD儿童的弟弟妹妹的母乳喂养（BF）时长，并确定较长的BF时长是否与该队列中神经发育结果的差异相关。通过MARBLES（婴儿自闭症风险标志物——学习早期体征）研究中的调查收集了有关BF情况的信息。由专业临床医生进行发育评估，包括莫伦早期学习量表和自闭症诊断观察量表。参与者的神经发育结果通过一种算法分为三组：典型发育、ASD和非典型发育。BF的中位时长为10.70个月（四分位间距为12.07个月）。在三个神经发育结果类别中，BF时长的分布没有显著差异。与母乳喂养0 - 3个月的儿童相比，该高风险队列中母乳喂养超过12个月的儿童在认知测试中的得分显著更高。基于BF时长，ASD症状或ASD风险没有显著差异。
