Yong Xuhong, Wang Bi, Wang Mengdi, Lyu Hui, Yin Min, Jin Tong, Feng Xu, Shan Yu, Liang Yan, Wang Qizhi
Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Jiangsu Province Engineering Research Center of Eco-Cultivation and High-Value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
Nanjing University of Chinese Medicine, Nanjing 210023, China.
Molecules. 2024 Feb 28;29(5):1059. doi: 10.3390/molecules29051059.
The genus comprises numerous untapped medicinal plants that warrant thorough evaluation for their potential as valuable natural sources of herbal medicine or food flavorings. In this study, untargeted metabolomics and in vitro functional methods were employed to analyze fruit extracts from 11 significant species of the genus. An investigation of the distribution of metabolites (quinolone and indole quinazoline alkaloids) in these species indicated that () was the most widely distributed species, followed by (), (), (), and (). There have been reports on the close correlation between indole quinazoline alkaloids and their anti-tumor activity, especially in fruits which exhibit effectiveness against various types of cancer, such as SGC-7901, Hela, A549, and other cancer cell lines. Additionally, the plant contains indole quinazoline alkaloids, which possess remarkable antibacterial properties. Our results offer novel insights into the utilization of resources in the pharmaceutical industry.
该属包含众多未开发的药用植物，有必要对其作为珍贵天然草药来源或食品调味剂的潜力进行全面评估。在本研究中，采用非靶向代谢组学和体外功能方法分析了该属11个重要物种的果实提取物。对这些物种中代谢物（喹诺酮和吲哚喹唑啉生物碱）分布的调查表明，（）是分布最广的物种，其次是（）、（）、（）和（）。已有报道表明吲哚喹唑啉生物碱与其抗肿瘤活性密切相关，尤其是在对多种类型癌症（如SGC - 7901、Hela、A549等癌细胞系）具有疗效的（）果实中。此外，（）植物含有吲哚喹唑啉生物碱，具有显著的抗菌特性。我们的研究结果为该属资源在制药行业的利用提供了新的见解。
